Immuneresponse to nanostructured neural probes

In our study, bioactive properties of Si nanopillars compared to microstructured Si surfaces were investigated after being implanted for eight weeks, in vivo. To form the randomly nanostructured surfaces, we utilise black polycrystalline silicon (poly-Si) thin film. The advantage of black poly-Si is that its production can be integrated into the fabrication scheme of Michigan type silicon neural microelectrodes. Our results suggest that surface topography can alter the effect of implantation regarding the preservation of neurons in a distance of 0–50 μm from the track.

Nanostructuring the implant surface may be favourable for long-term applications as a larger neuronal density remains in the vicinity of a nanostructured surface and may provide better signal-to-noise ratio during electric recordings.

Z. Fekete, Á. Horváth, Zs. Bérces, A. Pongrácz: Black poly-silicon: a nanostructured seed layer for sensor applications, Sensors and Actuators A: Physical 216 (2014) 277-286

Zs. Bérces, K. Tóth, G. Márton, I. Pál, B. Kováts-Megyesi, Z. Fekete, I. Ulbert, A. Pongracz, Neurobiochemical changes in the vicinity of a nanostructured neural implant. Scientific Reports 6 (2016) 35944