We presented in vivo local iontophoretic release of a neuronal tracer, biotinylated dextran amine (BDA) in the rat brain using monolithically integrated microfluidic channel embedded in a neural multielectrode. The tracer injection is controlled by iontophoresis using Pt electrodes in the vicinity of the outlet of the microfluidic channel. The microdevice is capable of simultaneous in vivo multichannel neural recording and controlled tracer injection for mapping neuronal pathways of the brain.
Z. Fekete, E. Pálfi, G. Márton, M. Handbauer, Zs. Bérces, I. Ulbert, A. Pongrácz, L. Négyessy: In vivo iontophoretic BDA injection through a buried microfluidic channel of a neural multielectrode, Procedia Engineering 120 (2015) 464-467
Z. Fekete. E. Pálfi, G. Márton, M. Handbauer, Zs. Bérces, I. Ulbert, A. Pongrácz, L. Négyessy, Combined in vivo recording of neural signals and iontophoretic injection of pathway tracers using a hollow silicon microelectrode, Sensors & Actuators B-Chemical (2016), in press