Bsc/Msc topics

Latest update: 13/01/2019

Foreigners interested in doing their bachelor, master study in our lab are welcome to contact us via e-mail

Topic: Measurement automation to control brain-machine interfaces
Supervisor:
Á. Cs. Horváth

Multifunctional optical actuators implantable into neural tissue
are manufactured in the MEMS lab of MTA EK MFA. The applicant has to create a
Matlab or Labview-based control system which can realize neural stimulation by
the infrared irradiation of the optical actuators, and based on the registered
input data of the integrated sensors of the optical actuator (tissue
temperature, electrophysiological signals) the stimulating parameters during
further in vitro and in vivo experiments can be adjusted and controlled in
constant and pulsed mode as well. Hardware components and necessary software
are all available. This topic is suitable for a further desired TDK work.

Topic: Infrared neural stimulation using novel
brain-machine interfaces

Supervisor:
Á. Cs. Horváth

It is
known from experiments that changes in body temperature affect electrical signals
and metabolic processes in the brain. In the MEMS lab of MTA EK MFA
microsystems implantable into neural tissue are manufactured for exploring
these connections. The applicant has to observe the functioning of the
integrated thermal sensors and optical actuators in experimental conditions,
and has to calibrate them in vitro. Beyond designing and assemling the
measuring system the applicant has to fulfil documented functional tests of the
implantable microtools. This topic is suitable for a further desired TDK work.

Topic: Process development to optimize polymer based brain-machine
interfaces

Supervisor:
A. Zátonyi

Our research group is developing flexible, less invasive, 
polymer based microelectrode arrays that fits to the curvilinear surface of the
brain. Among our expectations arrays should be able to record high temporal
resolution electrophysiology signals from the cortical surface combined with
high spatial resolution imaging techniques. Its microfabrication relies on MEMS
(Micro-Electro-Mechanical Systems) technologies including photolithography,
bulk micromachining and thin film deposition. The applicant will be involved in
the semiconductor and microtechnology process and has to optimize diverse
microfabrication steps. Experimental result will be evaluated using optical and
scanning electron microscopy.

Topic:
Development of image processing tools to investigate the interaction of
neuronal cells and nanostructured SU8 polymer interfaces

Supervisor:
Á. Szabó

Foreign
body response to neural implants is of high importance affecting device
functionality of current neuroprosthetic devices. The applicant may join an
ongoing research on the interaction of nanostructured SU-8 polymer surfaces and
neural cells. Evaluation of in vitro assays should be performed based on
fluorescent microscopy and image processing in Matlab. Detection of cells,
their viability and attachment of various surface topographies should be
implemented and analyzed. Development of detection algorithms should be also
able to address the evolution of dendrite and axon growth.