Lectures notes

Title: Applications of neural microsystems (P-ITBIO-0042)
Credit value: 3
Category of the subject: optional for students attending Infobionics Engineering Msc at PPCU
Subject owner: Dr. Zoltan Fekete
Teachers involved: Dr. Ágoston Csaba Horváth, Dr. Richárd Fiáth, Dr. Ágnes Szabó, Zsófia Balogh-Lantos 

Description: this course provides comprehensive insight into the interdisciplinary field of neural microsensors and actuators relying on the recent advances in both material- and neuroscience. Operation principles, technological challenges will be addressed through real applications. Main topics included in the lectures:

1.  History of microscale implants for central and peripheral nervous system research

2. Fundamental technological background I.

3. Fundamental technological background II.

4. Multimodal sensor/stimulator arrays relying on integrated signal processing units

5. Introduction into the material selection in terms of functionality, processing and biocompatibility

6. Materials, technology and applications of flexible soft implants, microECoGs and peripheral nerve stimulator

7. Optogenetics and challenges in optoelectronic microsystem design

8. Thermogenetics and implantable microsystems for infrared neural stimulation

9. Integrated drug delivery solutions in microelectrode arrays

10. Mechanical interaction between implanted device and neural tissue

11. Influence of physical and chemical properties of microimplant surfaces on long-term stability

12. Transparent epidural implants for multimodal neuroimaging 


Compulsory: handout of the lectures.


K.D. Wise et al, Microelectrodes, Microelectronics, and
Implantable Neural Microsystems, Proceedings of the IEEE 96 (2008) 1184-1202

Z. Fekete et al., Multifunctional soft implants to
monitor and control neural activity in the central and peripheral nervous
system: a review, Sensors & Actuators B-Chemical 243 (2017) 1214-1223

Z. Fekete, Recent advances in silicon-based neural
microelectrodes and microsystems: a review, Sensors & Actuators B-Chemical
215 (2015) 300-315